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Mattioli is an Italian surname. Notable people with the surname include:Alessandro Mattioli, Italian footballer Carlo Mattioli, Italian race walker Denise Mattioli, Brazilian volleyball player Ercole Antonio Mattioli (1640–1694), Italian minister Gaspare Mattioli (1806–1843), Italian painter Gianni Francesco Mattioli, Italian politician and university professor Girolamo Mattioli, Italian painter and engraver Italo Mattioli, Italian professional football player Ludovico Mattioli (1662-1747), Italian painter and engraver Luisa Mattioli (1936–2021), Italian actress Marcus Mattioli, Brazilian swimmer Mario Mattioli (1945–2003), Italian volleyball player Massimo Mattioli (1943–2019), Italian cartoonist Mattiolo Mattioli, Italian author Maurizio Mattioli, Italian actor and comedian Pietro Andrea Mattioli (1501–1577), Italian herbalist Raffaele Mattioli, Italian painter Rocky Mattioli, Italian-Australian former boxing world champion